TL-19-87E3E1 SYGNOMICS Report
01/09/2022
SOC Drugs
# 1. Target: GSR
Drugs
Model Evidence
7 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
2. Target: VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
Drugs in GBM Trials
# 1. Target: WEE1
Drugs
Model Evidence
11 regulons containing the target(s), WEE1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
FDA Approved Drugs
# 1. Target: APP
Drugs
Model Evidence
41 regulons containing the target(s), APP are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
2. Target: SV2A
Drugs
Model Evidence
2 regulons containing the target(s), SV2A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
3. Target: KEAP1
Drugs
Model Evidence
4 regulons containing the target(s), KEAP1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
4. Target: HBB
Drugs
Model Evidence
2 regulons containing the target(s), HBB are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
5. Target: GSR
Drugs
Model Evidence
7 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
6. Target: ABL1
Drugs
Model Evidence
5 regulons containing the target(s), ABL1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
7. Target: BSG
Drugs
Model Evidence
2 regulons containing the target(s), BSG are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
8. Target: NDUFA13
Drugs
Model Evidence
5 regulons containing the target(s), NDUFA13 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
9. Target: TSG101
Drugs
Model Evidence
2 regulons containing the target(s), TSG101 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
10. Target: NOTCH1
Drugs
Model Evidence
4 regulons containing the target(s), NOTCH1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_NOTCH_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
11. Target: ABAT
Drugs
Model Evidence
17 regulons containing the target(s), ABAT are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
12. Target: PLA2G2A
Drugs
Model Evidence
2 regulons containing the target(s), PLA2G2A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
13. Target: TRPV4
Drugs
Model Evidence
1 regulons containing the target(s), TRPV4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
14. Target: UGCG
Drugs
Model Evidence
50 regulons containing the target(s), UGCG are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
15. Target: CA2
Drugs
Model Evidence
14 regulons containing the target(s), CA2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
16. Target: ANGPT2
Drugs
Model Evidence
24 regulons containing the target(s), ANGPT2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
17. Target: ANGPT2,VEGFA
Drugs
Model Evidence
32 regulons containing the target(s), ANGPT2,VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
18. Target: VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
19. Target: EEF2
Drugs
Model Evidence
10 regulons containing the target(s), EEF2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
20. Target: TNC
Drugs
Model Evidence
9 regulons containing the target(s), TNC are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
21. Target: MAPK1,MAPK3
Drugs
Model Evidence
18 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
22. Target: HRH1
Drugs
Model Evidence
42 regulons containing the target(s), HRH1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
23. Target: PLA2G2A,PLA2G5
Drugs
Model Evidence
7 regulons containing the target(s), PLA2G2A,PLA2G5 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
24. Target: SLC6A9
Drugs
Model Evidence
13 regulons containing the target(s), SLC6A9 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
25. Target: ANGPT1,ANGPT2
Drugs
Model Evidence
24 regulons containing the target(s), ANGPT1,ANGPT2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
26. Target: HRH1,SLC6A2
Drugs
Model Evidence
42 regulons containing the target(s), HRH1,SLC6A2 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
27. Target: SOD1
Drugs
Model Evidence
5 regulons containing the target(s), SOD1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
28. Target: ACVR2B
Drugs
Model Evidence
5 regulons containing the target(s), ACVR2B are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
29. Target: CA2,CA4
Drugs
Model Evidence
14 regulons containing the target(s), CA2,CA4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
30. Target: OXTR
Drugs
Model Evidence
9 regulons containing the target(s), OXTR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
31. Target: PGF,VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), PGF,VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
32. Target: SERPINE1
Drugs
Model Evidence
45 regulons containing the target(s), SERPINE1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_TGF_BETA_SIGNALING HALLMARK_UV_RESPONSE_DN HALLMARK_APOPTOSIS HALLMARK_COMPLEMENT
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
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